Adrenal cancer

Updated: 2023-04-26

Overview

Adrenal glands

Located on top of each kidney, the adrenal glands make hormones that help regulate metabolism, the immune system, blood pressure and other important functions. Although small, these glands control much of what happens in the body.

Adrenal cancer is a rare cancer that begins in one or both of the small, triangular glands (adrenal glands) located on top of your kidneys. Adrenal glands produce hormones that give instructions to virtually every organ and tissue in your body.

Adrenal cancer, also called adrenocortical cancer, can occur at any age. But it's most likely to affect children younger than 5 and adults in their 40s and 50s.

When adrenal cancer is found early, there is a chance for cure. But if the cancer has spread to areas beyond the adrenal glands, cure becomes less likely. Treatment can be used to delay progression or recurrence.

Most growths that form in the adrenal glands are noncancerous (benign). Benign adrenal tumors, such as adenoma or pheochromocytoma, also can develop in the adrenal glands.

Symptoms

Signs and symptoms of adrenal cancer include:

• Weight gain
• Muscle weakness
• Pink or purple stretch marks on the skin
• Hormone changes in women that might cause excess facial hair, hair loss on the head and irregular periods
• Hormone changes in men that might cause enlarged breast tissue and shrinking testicles
• Nausea
• Vomiting
• Abdominal bloating
• Back pain
• Fever
• Loss of appetite
• Loss of weight without trying

Causes

It's not clear what causes adrenal cancer.

Adrenal cancer forms when something creates changes (mutations) in the DNA of an adrenal gland cell. A cell's DNA contains the instructions that tell a cell what to do. The mutations can tell the cell to multiply uncontrollably and to continue living when healthy cells would die. When this happens, the abnormal cells accumulate and form a tumor. The tumor cells can break away and spread (metastasize) to other parts of the body.

Risk factors

Adrenal cancer happens more often in people with inherited syndromes that increase the risk of certain cancers. These inherited syndromes include:

• Beckwith-Wiedemann syndrome
• Carney complex
• Li-Fraumeni syndrome
• Lynch syndrome
• Multiple endocrine neoplasia, type 1 (MEN 1)

Diagnosis

Tests and procedures used to diagnose adrenal cancer include:

• Blood and urine tests. Laboratory tests of your blood and urine may reveal unusual levels of hormones produced by the adrenal glands, including cortisol, aldosterone and androgens.
• Imaging tests. Your doctor may recommend CT, MRI or positron emission tomography (PET) scans to better understand any growths on your adrenal glands and to see if cancer has spread to other areas of your body, such as your lungs or your liver.
• Laboratory analysis of your adrenal gland. If your doctor suspects you may have adrenal cancer, he or she may recommend removing the affected adrenal gland. The gland is analyzed in a laboratory by a doctor who studies body tissues (pathologist). This analysis can confirm whether you have cancer and exactly what types of cells are involved.

Treatment

Adrenal cancer treatment usually involves surgery to remove all of the cancer. Other treatments might be used to prevent the cancer from coming back or if surgery isn't an option.

Surgery

The goal of surgery is to remove the entire adrenal cancer. To achieve this, doctors must remove the all of the affected adrenal gland (adrenalectomy).

If surgeons find evidence that cancer has spread to nearby structures, such as the liver or kidney, parts or all of those organs might also be removed during the operation.

Medication to reduce the risk of recurrence

An older drug that has been used to treat advanced adrenal cancer has shown promise in delaying the recurrence of the disease after surgery. Mitotane (Lysodren) may be recommended after surgery for people with a high risk of cancer recurrence. Research into mitotane for this use is ongoing.

Radiation therapy

Radiation therapy uses high-powered beams of energy, such as X-rays and protons, to kill cancer cells. Radiation therapy is sometimes used after adrenal cancer surgery to kill any cells that might remain. It can also help reduce pain and other symptoms of cancer that has spread to other parts of the body, such as the bone.

Chemotherapy

Chemotherapy is a drug treatment that uses chemicals to kill cancer cells. For adrenal cancers that can't be removed with surgery or that return after initial treatments, chemotherapy may be an option to slow the progression of the cancer.

Coping and support

With time, you'll find what helps you cope with the uncertainty and distress that comes with a cancer diagnosis. Until then, you may find it helps to:

• Learn enough about adrenal cancer to make decisions about your care. Ask your doctor about your cancer, including your test results, treatment options and, if you like, your prognosis. As you learn more about cancer, you may become more confident in making treatment decisions.
• Keep friends and family close. Keeping your close relationships strong will help you deal with your cancer. Friends and family can provide the practical support you'll need, such as helping take care of your house if you're in the hospital. And they can serve as emotional support when you feel overwhelmed by cancer.

• Find someone to talk with. Find a good listener who is willing to listen to you talk about your hopes and fears. This may be a friend or family member. The concern and understanding of a counselor, medical social worker, clergy member or cancer support group also may be helpful.

  Ask your doctor about support groups in your area. Other sources of information include the National Cancer Institute and the American Cancer Society.

Preparing for an appointment

Start by making an appointment with your doctor if you have any signs or symptoms that worry you.

Here's some information to help you get ready for your appointment.

What you can do

When you make the appointment, ask if there's anything you need to do in advance, such as fasting before having a specific test. Make a list of:

• Your symptoms, including any that seem unrelated to the reason for your appointment
• Key personal information, including major stresses, recent life changes and family medical history
• All medications, vitamins or other supplements you take, including the doses
• Questions to ask your doctor

Bring a family member or friend with you, if possible, to help remember the information you're given.

For adrenal cancer, some basic questions to ask your doctor include:

• What's likely causing my symptoms?
• Other than the most likely cause, what are other possible causes for my symptoms?
• What tests do I need?
• What's the best course of action?
• What are the alternatives to the primary approach you're suggesting?
• I have these other health conditions. How can I best manage them together?
• Are there restrictions I need to follow?
• Should I see a specialist?
• Are there brochures or other printed material I can have? What websites do you recommend?

Don't hesitate to ask other questions.

What to expect from your doctor

Your doctor is likely to ask you several questions, such as:

• When did your symptoms begin?
• Have your symptoms been continuous or occasional?
• How severe are your symptoms?
• What, if anything, seems to improve your symptoms?
• What, if anything, appears to worsen your symptoms?