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Clinical Research

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Our Commitment
The physicians at St. Elizabeth Healthcare are committed to providing the best and most current medical care for all patients. Through this commitment, our patients are eligible for participation in research trials sponsored by the National Cancer Institute and members of the NCI National Clinical Trials Network (NCTN).

For questions/additional information about clinical research trials, please contact:
Darla Hehman, BSN, RN, CCRC 
Oncology Research Nurse
Phone: (859) 301-5473
Fax: (859) 301-2607

Kim Schmidt, MSN, RN
Oncology Research Nurse
phone (859) 301-9418
fax   (859) 301-2607

Listed below are all of the clinical research trials that are open to patients at St. Elizabeth Healthcare.

Breast Cancer
ALLIANCE- A011106 Alternate Approaches for Clinical Stage II or III Estrogen Receptor Positive Breast Cancer  Neoadjuvant Treatment (ALTERNATE) in Postmenopausal Women

CALGB-40903 Phase II Study Neoadjuvant Letrozole for Postmenopausal Women with Estrogen Receptor Positive Ductal Carcinoma in SITU (DCIS)

ACOSOG-Z11102 Impact of Breast Conservation Surgery on Surgical Outcomes and Cosmesis in Patients with Multiple Ipsilateral Breast Cancers (MIBC)

ALLIANCE- A221102 - A Randomized Double-Blind Placebo Controlled Study of Subcutaneous Testosterone in the Adjuvant Treatment of Postmenopausal  Women with Aromatase Inhibitor Induced Arthralgia

NSABP B-51  - A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients with Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy

Ovarian Cancer
GOG-0225  Can Diet and Physical Activity Modulate Ovarian or Primary Peritoneal Cancer Progression-Free Survival? (Sponsor: Gynecologic Oncology Group)

This randomized phase III trial is studying diet and physical activity changes to see how well they work compared with usual care in improving progression-free survival of patients with previously treated stage II, stage III, or stage IV ovarian epithelial cancer, fallopian tube cancer, or primary peritoneal cancer.

Uterine Cancer
FIRES study “Determining the Sensitivity of Sentinel Lymph Nodes Identified With Robotic Fluorescence Imaging” (Sponsor: Indiana University)

This is a multi-institutional study investigating the sensitivity and negative predictive value of sentinel lymph nodes mapped with robotic assisted near infrared imaging after cervical injection of indocyanine green (ICG) dye for women with stage I endometrial or cervical cancer at the time of their robotic surgical staging.

GOG-0238  A Randomized Trial of Pelvic Irradiation with or without Concurrent Weekly Cisplatin in Patients with Pelvic-only Recurrence of Carcinoma of the Uterine Corpus (Sponsor: Gynecologic Oncology Group)

This randomized phase II trial is studying radiation therapy and cisplatin to see how well they work compared with radiation therapy alone in treating patients with recurrent endometrial cancer.

  A Randomized Phase II/III Study of Paclitaxel/Carboplatin/Metformin (NSC#91485) Versus Paclitaxel/Carboplatin/Placebo as Initial Therapy for Measurable Stage III or IVA, Stage IVB, or Recurrent Endometrial Cancer” (Sponsor: NRG Oncology)

A Phase III Randomized Trial of Pulse Actinomcyin-D versus Multi-day Methotrexate for the Management of Low Risk Gestational Trophoblastic Neoplasia (Sponsor: Gynecologic Oncology Group)

This randomized phase III trial is studying the effectiveness of two standard types of chemotherapy treatment and explores factors that may influence quality of life in patients diagnosed with low-risk gestational trophoblastic neoplasia.

Additional Resources
We encourage patients to explore additional information about clinical trials provided by the National Cancer Institute or the American Cancer Society. Also, The American Cancer Society provides a free, confidential Clinical Trials Matching Service that helps patients, their families and health care workers find cancer clinical trials most appropriate to a patient's medical and personal situation.

Click on the NIH Clinical Research Trials and You link for information about the risks and benefits of taking part in a clinical trial, how to find a trial, and questions to ask when considering participation in a trial.

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